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| Product Name | CTCFL, Recombinant, Mouse, aa1-636, His-SUMO-Tag (Transcriptional Repressor Ctcfl) |
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| Description | Purity ~90% (SDS-PAGE). Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites. Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters. Source: Recombinant protein corresponding to aa1-636 from mouse CTCFL, fused to His-SUMO-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~89.1kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Brother of the regulator of imprinted sites CCCTC-binding factor CTCF paralog, CTCF-like protein |
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| Gene, Accession, CAS # | SwissProt: A2APF3 |
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| Catalog # | 372900 |
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| Order / More Info | CTCFL, Recombinant, Mouse, aa1-636, His-SUMO-Tag (Transcriptional Repressor Ctcfl) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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