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| Product Name | 4-1 BB Ligand, Recombinant, Human |
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| Description | Purity ≥ 98% by SDS-PAGE and HPLC. Human 4-1BB Ligand (4-1BBL, CD137L) is a 32kD type II transmembrane protein that belongs to TNF superfamily (TNFSF) of molecules.1-4 The human 4-1BBL cDNA encodes a 254 amino acid (aa) protein that contains a 25aa N-terminal cytoplasmic domain, a 23aa transmembrane segment, and a 206aa C-terminal extracellular region.5 The extracellular domain (ECD) of 4-1BBL has a jelly-roll, β-sandwich tertiary structure that is similar to other TNFSF members. There is only one cysteine in the human ECD, and no potential N-linked glycosylation sites. The potential exists, however, for O-linked glycosylation. The human 4-1BBL ECD shares 32% and 35% aa identity with mouse and rat ECD, respectively. In the cytoplasmic domain, human 4-1BBL is 55aa shorter than the equivalent region in rodents. 4-1BBL is expressed by activated B cells, macrophages, dendritic cells, activated Tcells, neurons and astrocytes.2, 3, 6 A 26kD soluble form of 4-1BBL is known to occur in hu |
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| Size | 5ug, 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-1 BB Ligand, Recombinant, Human (4-1BBL, CD137L, TNFSF9, Tumor necrosis factor ligand superfamily member 9) |
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| Gene, Accession, CAS # | Accession: NP_003802 |
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| Catalog # | 0004-01 |
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| Order / More Info | 4-1 BB Ligand, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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