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| Product Name | Autophagy Inhibitor IV, Cpd18 (3-methyl-6-(3-methylpiperidin-1-yl)-3H-purine, 3-MA analog, Cpd 18) |
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| Description | Purity ~98% (HPLC). A cell-permeable 3-methyladenine (3-MA) derivative that acts as an autophagy inhibitor via the inhibition of class III PI3K, and without touching class I PI3K. Shown to block 80% of starvation-induced autophagy at 1 mM (IC50 = 0.67mM, compared with 3-MA at 6 mM). Displays much better solubility than 3-MA (5 times more soluble in water and 30 times more soluble in DMSO). Also found to reduce cell viability by 55% at 1 mM at 12 hours compared with 72% reduction for 3-MA at 10mM. Please note that the molecular weight for this compound is lot-specific due to variable water content. Primary Target: PI3K Primary Target IC50: 0.67mM Solubility: DMSO |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217205 |
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| Order / More Info | Autophagy Inhibitor IV, Cpd18 (3-methyl-6-(3-methylpiperidin-1-yl)-3H-purine, 3-MA analog, Cpd 18) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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