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| Product Name | PKR Inhibitor III, 7DG |
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| Description | Purity ~95% (HPLC). A cell-permeable gedunin analog that directly targets PKR via reversible interaction inhibits PKR-mediated cellular events by disrupting PKR signaling complexes assembly, such as IkK complex and inflammasome/pyroptosome, resulting in effective blockage of LPS-induced IkBbeta degradaion (20uM) and protection against anthrax toxin LT-induced caspase-1 activation as well as subsequent pyroptosis (10uM) in murine macrophage J774 cultures. PKR is also known to mediate LT-induced apoptosis via its kinase activity in LPS-primed Macrophages derived from C57BL/6 with a resistent NLRP1 allele, inhibitable by C16, but not by 7DG, while LT-induced pyroptosis in J774 cultures is insensitive to C16 treatment. Solubility: DMSO Primary Target: PKR |
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| Size | 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PKR Inhibitor III, 7DG (Double-stranded RNA-activated Protein Kinase Inhibitor III, EIF2AK2 Inhibitor III, 7-Desacetoxy-6,7-dehydrogedunin, Double-stranded RNA-dependent Protein Kinase Inhibitor III) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217675 |
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| Price | |
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| Order / More Info | PKR Inhibitor III, 7DG from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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