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| Product Name | Protein CYR61, active (CYR61), Recombinant, Human |
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| Description | Purity ≥95% as determined by SDS-PAGE and HPLC. Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. (ECO:0000269|PubMed:11584015). Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/3T3 cells is less than 3.0ug/ml, corresponding to a specific activity of 330 IU/mg. |
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| Size | 5ug, 20ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CCN family member 1, Insulin-like growth factor-binding protein 10, IBP-10, IGF-binding protein 10, IGFBP-10 |
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| Gene, Accession, CAS # | CYR61_HUMAN, SwissProt: O00622 |
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| Catalog # | 348216 |
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| Order / More Info | Protein CYR61, active (CYR61), Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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