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| Product Name | Protein C, Activated, Dansyl EGR, Human (APC) |
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| Description | Purity ≥95%. Activated protein C is prepared from purified protein C by activation with thrombin followed by ion exchange chromatography (4). Purity is determined by SDS-PAGE analysis. Inactivation of Factor Va by Activated Protein C (APC): The inactivation of factor Va to form factor Vai results from proteolysis of the factor Va heavy chain (94K) at three specific sites by APC (1,2). The location of these cleavage sites in the factor Va heavy chain are as follows: (human: R306, R506, & R679) and (bovine: R306, R505, & R662). Complete inactivation of the cofactor molecule requires cleavage at the Arginine-306 position. Cleavage at Arginine-306 by activated protein C occurs only in the presence of membrane, and requires prior cleavage of the heavy chain at Arginine-505. Proteolysis of the factor Va light chain by APC occurs only in the bovine molecule and is not required for inactivation. Activated protein C (APC) is an anticoagulant serine protease derived from the two chain, vitamin K |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | P9081-04 |
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| Order / More Info | Protein C, Activated, Dansyl EGR, Human (APC) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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