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| Product Name | Akt Activator II, SC79 |
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| Description | Purity ~98% (HPLC). A cell-permeable and blood-brain barrier permeant HA14-1 analog that interacts with Akt PH domain PtdIns(3,4,5)P3- (PIP3) binding pocket, rendering Akt in a conformation susceptible to phosphorylation by upstream kinases. Shown to enhance both basal and receptor-mediated Akt phosphorylation (Thr308 and Ser473; 2 to 4ug/ml) with concomitant inhibition Akt membrane translocation in various cell cultures. Efficiently reduces glutamate-induced neurotoxicity both in primary neuron cultures (EC50 = 4ug/ml) in vitro and in a murine MCAO model (40mg/kg, i.p.) in vivo. Solubility: DMSO Primary Target: Pleckstrin homology (PH) domain of Akt Molar Mass: 364.8 |
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| Size | 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Akt Activator II, SC79 (Ethyl-2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217169 |
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| Order / More Info | Akt Activator II, SC79 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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