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| Product Name | Exotoxin A, Pseudomonas aeruginosa |
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| Description | Exotoxin A is one of the toxic proteins released by pathogenic strains of Pseudomonas aeruginosa. It is secreted as a proenzyme with a molecular weight of 66kD. Like diphtheria toxin, exotoxin A is translocated into susceptible mammalian cells. Covalent alteration of the molecule occurs, rendering it enzymatically active. The intact toxin can be activated 20- to 50-fold in vitro by treatment with urea and dithiothreitol. Exotoxin A catalyzes the transfer of the adenosine diphosphate ribose moiety of oxidized nicotinamide adenine dinucleotide onto elongation factor 2(3): NAD + EF-2 ® ADP-ribose-EF-2 + nicotinamide + H+. This ADP-ribosylation of EF-2 blocks polypeptide assembly on the surface of the ribosome. As a result, this molecule is cytopathic for a number of cultured cell lines and is toxic to animals. Although exotoxin A and diphtheria toxin have identical enzymatic activity, they exhibit distinct target cell specificities and are immunologically unrelated. In crude preparations |
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| Size | 1mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 215940 |
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| Price | |
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| Order / More Info | Exotoxin A, Pseudomonas aeruginosa from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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