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| Antigenic Specificity | Pannexin 2 (PANX2) (aa 11-664) |
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| Clone | S121A-31 |
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| Host Species | Mouse |
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| Reactive Species | rat |
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| Isotype | n/a |
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| Format | Atto 633 conjugate |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (IHC),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Gap junctions are formed by a hexameric group of proteins called connexions for the transport of low molecular weight proteins from cell to cell. Connexins, which are present in all metazoan organisms, serve diverse functions ranging from control of cell growth and differentiation to electric conduction in excitable tissues. Several mammalian cells with malignant phenotypes exhibit decreased connexin expression and gap junction communication. The pannexin gene family encodes a second class of putative gap junction proteins. Pannexins are highly conserved in invertebrates and mammals, indicating the importance of their gap junctional coupling function. Mammalian Pannexin-1 and Pannexin-3 are closely related, while Pannexin-2 is more distantly related. Pannexin-2 is a transmembrane protein expressed in the central nervous system that is unable to assemble in homomeric channels but forms heteromeric channels with Pannexin-1.Cellular Localization: Cell Membrane, Cell Junction | Gap junction |
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| Immunogen | Fusion protein amino acids 11-664 (all but first 10 amino acids, encompassing extracellular and cytoplasmic domains) of rat Pannexin-2 |
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| Other Names | PANX2|si:ch211-192n14.2|PX2|hPANX2 |
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| Gene, Accession # | Gene ID: 362979 |
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| Catalog # | ABIN2482904 |
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| Price | |
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| Order / More Info | Pannexin 2 (PANX2) (aa 11-664) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 15028292, 14597722 |
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