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| Product Name | Neudesin, Recombinant, Human, aa32-172 |
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| Description | Purity ~95% (SDS-PAGE). Neudesin (neuronderived neurotrophic secreted protein), gene name NENF (neudesin neurotrophic factor), also called CIR2 (cell immortalizationrelated 2) or GIG47, is a secreted, 2021kD member of the MAPR (membraneassociated progesterone receptor) subfamily of the cytochrome b5 family of molecules (1, 2). Human Neudesin is synthesized as a 172 amino acid (aa) precursor that contains a 31 aa signal sequence with a 141aa mature region that possesses a cytochrome b5like hemebinding domain over aa44129, and a lysine acetylation site at aa136 (14). The attachment of hemin to its hemebinding domain is necessary for its neurotrophic activity, and the binding of heme accounts for 56kD of its circulating molecular weight (3). Mature human Neudesin shares 97%, 94% and 96% aa identity with mouse, rat, and bovine Neudesin, respectively. Neudesin appears to selectively promote cell survival or proliferation and inhibit differentiation in multiple settings. It is expr |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Neudesin, Recombinant, Human, aa32-172 (CIR2, NENF, SCIRP10, SPUF, Neuron-derived Neurotrophic Secreted Protein) |
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| Gene, Accession, CAS # | SwissProt: Q9UMX5 |
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| Catalog # | 145824 |
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| Order / More Info | Neudesin, Recombinant, Human, aa32-172 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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