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| Product Name | GCK, Recombinant, Human, GST-Tag (Germinal Center Kinase, MAP4K2, BL44, RAB8IP) |
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| Description | Purified (~70-90%). GCK is a serine/threonine protein kinase that is activated by TNFa and interacts with the TNF receptor-associated factor 2 (TRAF2). GCK is upstream of MAP kinases and particularly activates the SAPK pathway. Although GCK is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. A mouse protein Rab8ip that has high homology to GCK can interact with the vesicular transport protein Rab8. Based on its interaction with Rab8, it is postulated that Rab8ip/GCK may modulate secretion in response to stress stimuli. Source: Recombinant protein corresponding to human GCK, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~125kD Specific Activity: 290nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NM_004579 |
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| Catalog # | 500033 |
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| Order / More Info | GCK, Recombinant, Human, GST-Tag (Germinal Center Kinase, MAP4K2, BL44, RAB8IP) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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