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| Product Name | NONO, Recombinant, Human, aa1-471, His-SUMO-Tag (Non-POU Domain-containing Octamer-binding Protein) |
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| Description | Purity ~90% (SDS-PAGE). DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRC |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | NonO protein, 54kD nuclear RNA- and DNA-binding protein, 55kD nuclear protein, DNA-binding p52/p100 complex, 52kD subunit NMT55 p54(nrb), p54nrb |
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| Gene, Accession, CAS # | SwissProt: Q15233 |
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| Catalog # | 374440 |
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| Order / More Info | NONO, Recombinant, Human, aa1-471, His-SUMO-Tag (Non-POU Domain-containing Octamer-binding Protein) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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