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| Product Name | Gap Junction Enhancer, PQ7 |
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| Description | Purity ~98% (HPLC). A cell-permeable quinoline derived compound with low toxicity that enhances gap junctional activity by about 16-fold (at ~500nM) in T47D breast cancer cells and thereby potentiates the effect of chemotherapeutic agents. Blocks T47D cell colony formation (IC50 = 100nM) and reduce the growth of T47D xenograft tumors by 100% in Nu/Nu mice. Increases caspase-3, - 8, and -9 expression by 1.6, 2.8, and 3.8-fold, respectively to induce apoptotic cell death. Can work synergistically with cisplatin to reduce or totally eliminate tumor growth. Increases the expression of connexins 26, 32, and 43 to allow more efficient trafficking of cisplatin. Primary Target IC50: 100nM Solubility: DMSO |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217379 |
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| Order / More Info | Gap Junction Enhancer, PQ7 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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