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| Product Name | LATS1, Recombinant, Human, GST-Tag (Large Tumor Suppressor Homolog 1, WARTS, Wts) |
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| Description | Purified (~70-90%). LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis which is phosphorylated in a cell-cycle dependent manner. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity which indicating a role as a negative regulator of CDC2/cyclin A and the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. LATS1 act as a tumor suppressor and play an important role in the development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. Source: Recombinant protein corresponding to human LATS1, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~95kD Specific Activity: 1.4nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NM_004690, SwissProt: O95835 |
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| Catalog # | 500204 |
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| Order / More Info | LATS1, Recombinant, Human, GST-Tag (Large Tumor Suppressor Homolog 1, WARTS, Wts) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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