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| Antigenic Specificity | Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (aa 216-434) |
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| Clone | SLP-76-03 |
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| Host Species | Mouse |
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| Reactive Species | human, porcine, mouse |
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| Isotype | IgG2b |
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| Format | Protein G purified |
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| Size | 0.1 mg |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | SLP76 (SH2 domain-containing leukocyte protein of 76 kDa) is a cytosolic adaptor protein which translocates to the plasma mambrane and is involved in multiple signaling pathways in T cells, mast cells, neutrophils and platelets, B cells express its analog SLP65/BLNK (B cell linker protein). SLP76 is phosphorylated by Syk-family and Tec-family tyrosine kinases and couples them to the phosphorylation and activation of PLC-gamma. Via Gads or Grb2, SLP76 also associates with LAT adaptor by involvement of SLP76 proline-rich region. The SH2 domain of SLP76 has been identified as the region involved in binding the serine/threonine kinase HPK1. HPK1 may act as both a positive and a negative regulator by promoting the Jnk-mitogen activated protein kinase (MAPK) pathway and inhibiting the pathway leading to AP-1 activation. |
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| Immunogen | Bacterially expressed fusion protein representing amino acids 216-434 of human SLP76 with histidine tag |
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| Other Names | AI323664|BB161688|SLP-76|SLP76|twm|Slp76 |
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| Gene, Accession # | Gene ID: 3937,100511843,16822 |
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| Catalog # | ABIN94466 |
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| Price | |
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| Order / More Info | Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (aa 216-434) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 16479002, 17148460, 16493428, 10377180 |
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