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| Product Name | 96-well Checkpoint Kinase Activity Assay Kit |
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| Description | Background: Cdc25C is a protein phosphatase responsible for dephosphorylating and activating Cdc2, a critical step in regulating mitosis in eukaryotic cells. Cdc25C is constitutively phosphorylated at Ser216 throughout interphase by c-TAK1 (Cdc25C associated protein kinase), while phosphorylation at this site is DNA damage dependent at the G2/M checkpoint. Prior to mitosis, checkpoint kinases (CHK1 and CHK2) can be activated in response to DNA damage, phosphorylating Cdc25C at Ser216, ultimately |
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| Size | 96 assays, 480 assays, |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | MBS168744 |
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| Order / More Info | 96-well Checkpoint Kinase Activity Assay Kit from MYBIOSOURCE INC. |
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| Product Specific References | 1. Zhou, B. B., and Elledge, S. J. (2000) Nature 408, 433-4392. Matsuoka, S., Huang, M., and Elledge, S. J. (1998) Science 282, 1893-18973. Ahn, J., Urist, M., and Prives, C. (2004) DNA Repair 3, 1039-10474. Ahn, J., and Prives, C. (2002) J. Biol. Chem. 277, 48418-48426 |
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