| 产品详情 |
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| Product Name | Casein Kinase II Inhibitor XII, TBBz |
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| Description | Purity ~99% (HPLC). A cell-permeable halogenated benzimidazole compound that acts as a selective and ATP competitive inhibitor of casein kinase II (CK2, Ki = 70nM for the active hetero-tetrameric form). However, its effect on free CK2a and CK2a' subunits is significantly reduced (Ki = 510 and 400nM, respectively). Reported to reduce viability and proliferation in HeLa, Jurkat, and HL-60 cells (at ?25uM). Also shown to disrupt the promoter activity of CYP24A1 and down-regulates its endogenous and 1, 25-Vitamin D3 (1,25-D3)-induced expression in PC3 cells. Synergistically enhances the anti-tumor effect of 1, 25-D3 in a PC3 xenograft murine model. Primary Target: CK2 Primary Target Ki: 70nM Solubility: DMSO |
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| Size | 20mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Casein Kinase II Inhibitor XII, TBBz (4,5,6,7-Tetrabromobenzimidazole, CYP24A1 inhibitor, TBBz, CK2 Inhibitor, TBBz) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217253 |
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| Order / More Info | Casein Kinase II Inhibitor XII, TBBz from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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