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| Product Name | Casein Kinase I Inhibitor V, LH846 |
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| Description | Purity ~95% (HPLC). A cell-permeable benzothiazolo compound that acts a potent, selective, and reversible inhibitor of CKIg (IC50=290nM). Exhibits much reduced potency towards CKle and CKla isoforms (IC50=1.3 and 2.5uM, respectively). Does not affect the activity of CK2 or other kinases in a 59-protein kinase panel. Shown to block CKld-dependent period protein PER1 phosphorylation and diminish its proteasomal degradation in a dose-dependent manner. Also, shown to lengthen the circadian period in U2OS cells (10h at 8uM) without significantly affecting the amplitude of Per2-dLuc and Bmal1-dLuc rhythms. Formula: C16H13ClN2OS Molecular Weight: 316.8 |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Casein Kinase I Inhibitor V, LH846 (N-(5-Chloro-6-methyl-1,3-benzothiazol-2-yl)-2-phenylacetamide)(N-(5-Chloro-6-methylbenzo[d]thiazol-2-yl)-2-phenylacetamide) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217251 |
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| Order / More Info | Casein Kinase I Inhibitor V, LH846 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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