| 产品详情 |
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| Product Name | AN3365 (hydrochloride) |
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| Description | Purity >98%. AN3365 (hydrochloride) is a potent and selective bacterial leucyl-tRNA synthetase inhibitor active against Gram-negative bacteria. It is a member of a novel class of boron-containing compounds, the aminomethyl benzoxoaboroles, that have potential to combat multidrug resistance. It is active against many microbial strains, including strains of Enterobacteriaceae (MIC50/90 = 0.5/1 µg/ml) and the non-fermentative Gram-negative clinical isolates P. aeruginosa, A. baumannii, S. maltophilia, and B. cepacid (MIC50/90 s = 4/8, 4/8, 2/4, and 8/32 µg/ml, respectively). However, in a Phase II clinical trial for complicated urinary tract infections, bacterial resistance occurred very rapidly and the study was terminated. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-[[(3S)-3-(aminomethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborol-7-yl]oxy]-1-propanol, monohydrochloride, Epetraborole, GSK2251052 |
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| Gene, Accession, CAS # | CAS: 1234563-16-6 |
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| Catalog # | LS-H6534 |
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| Order / More Info | AN3365 (hydrochloride) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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