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| Antigenic Specificity | C-C Chemokine Receptor Type 5 (CCR5) |
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| Clone | T227 |
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| Host Species | Rat |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | fluorescein (FITC) conjugate |
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| Size | 1 mL |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FACS) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD195/CCR5, is a seven transmembrane receptor that is a member of the β-chemokine receptor family. CCR5 is expressed by T cells and macrophages, and is one of the two major co- receptors for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with resistance to HIV infection, and early infection with HIV-1 is dominated by CCR5-tropic viruses. The ligands of the CCR5 receptor include MCP-2, MIP-1a, MIP-1β, and RANTES. CCR5 is phosphorylated at specific sites by protein kinase C and GPCR kinase, and data show that two distinct forms of CCR5 protein, 62 and 42 kDa, are present in lymphocytic cells. CCR5 expression was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation.Synonyms: C-C CKR-5, C-C chemokine receptor type 5, CC-CKR-5, CCR-5, CHEMR13, CMKBR5, HIV-1 fusion coreceptor |
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| Immunogen | Syngeneic human CD195 transfectants |
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| Other Names | AM4-7|CD195|Cmkbr5|Ckr5|CC-CKR-5|CCR-5|CMKBR5|GPCR|CCR5|CCCKR5|CKR-5|CKR5|IDDM22 |
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| Gene, Accession # | Gene ID: 1234 |
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| Catalog # | ABIN2853594 |
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| Order / More Info | C-C Chemokine Receptor Type 5 (CCR5) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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