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| Product Name | HIF-1A, Recombinant, Human, aa331-609, GST-tag |
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| Description | Purity ~48% (SDS-PAGE, Coomassie blue staining). HIF-1a is the oxygen sensitive subunit of the hypoxia inducible factor HIF-1 which is an essential mediator of the cellular oxygen-signalling pathway. Under hypoxic conditions HIF-1a activates the transcription of over 40 genes, including those that control glucose uptake, metabolism, angiogenesis, erythropoiesis, cell proliferation, and apoptosis. The expression of HIF-1a is commonly increased in a variety of human tumours, and correlates with poor patient prognosis. Under normoxia this protein interacts with the ubiquitin ligase VHL complex, leading to its polyubiquitination and subsequent proteasomal degradation. Source: Recombinant corresponding to aa331-609 from human HIF-1a, fused to GST-tag at N-terminal c-Myc, expressed by baculovirus in Sf21 insect cells. Molecular Weight: ~60kD |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | HIF-1A, Recombinant, Human, aa331-609, GST-tag (Hypoxia Inducible Factor 1 alpha, Hypoxia-inducible Factor 1-alpha, HIF1-alpha, HIF-1alpha, HIF-1-alpha, HIF1, ARNT-interacting Protein, Basic-helix-loop-helix-PAS Protein MOP1, Class E Basic Helix-loop-helix Protein 78, bHLHe78, Member of PAS Protein 1, MOP1, PAS Domain-containing Protein 8, PASD8) |
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| Gene, Accession, CAS # | Accession: NM_001530 |
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| Catalog # | 29495 |
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| Order / More Info | HIF-1A, Recombinant, Human, aa331-609, GST-tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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