| 产品详情 |
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| Antigenic Specificity | Integrin alpha-L (ITGAL) (alpha subunit) |
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| Clone | MEM-83 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | Protein A purified |
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| Size | 0.1 mg |
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| Concentration | n/a |
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| Applications | Functional Studies (Func) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD11a (LFA-1 alpha) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the alphaLbeta2 integrin. CD11a is implicated in activation of LFA-1 complex. LFA-1 is expressed on the plasma membrane of leukocytes in a low-affinity conformation. Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation, which supports tight binding of LFA-1 to its ligands, the intercellular adhesion molecules ICAM-1, -2, -3. LFA-1 is thus involved in interaction of various immune cells and in their tissue-specific settlement, but participates also in control of cell differentiation and proliferation and of T-cell effector functions. Blocking of LFA-1 function by specific antibodies or small molecules has become an important therapeutic approach in treatment of multiple inflammatory diseases. For example, humanized anti-LFA-1 antibody Efalizumab (Raptiva) is being used to interfere with T cell migration to sites of inflammation, binding of cholesterol-lowering drug simvastatin to CD11a allosteric site leads to immunomodulation and increase in lymphocytic cholinergic activity. |
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| Immunogen | Human peripheral blood lymphocytes |
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| Other Names | (p180)|Cd11a|LFA-1|LFA-1A|Ly-15|Ly-21|CD11A|LFA1A|CD11a |
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| Gene, Accession # | Gene ID: 3683 |
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| Catalog # | ABIN125722 |
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| Price | |
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| Order / More Info | Integrin alpha-L (ITGAL) (alpha subunit) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 7518468, 19234188, 17289088, 17068975, 16918410, 7680657 |
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