产品详情 |
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Antigenic Specificity | TIM-4, Mouse |
Clone | Kat5-18 |
Host Species | Armenian hamster |
Reactive Species | mouse |
Isotype | IgG |
Format | unconjugated |
Size | 100 µg |
Concentration | 100 µg/ml |
Applications | FC, functional studies, immunoassay, IF |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The monoclonal antibody Kat5-18 recognizes T-cell immunoglobulin and mucin domain containing molecule (TIMD-4, also called TIM-4). TIMD-4 is a type I transmembrane protein belonging to the immunoglobulin superfamily, containing one Ig-like V-type (immunoglobulin-like) domain. TIMD-4 is expressed in Mac1+ cells in spleen, lymph nodes and fetal liver. TIMD-4 binds apoptotic cells by recognizing phosphatidylserine via its immunoglobulin domain. TIMD-4 in fibroblasts enhanced their ability to engulf apoptotic cells. TIMD-4 is involved in regulating T-cell proliferation and lymphotoxin signaling. TIMD-4 and TIMD-1 are phosphatidylserine receptors for the engulfment of apoptotic cells, and are also involved in intracellular signaling in which exosomes are involved. The monoclonal antibody Kat5-18 blocks the engulfment of apoptotic cells by thymic macrophages. |
Immunogen | Mouse peritoneal cells |
Other Names | TIMD4, TIM-4, T-cell immunoglobulin and mucin domain containing molecule |
Gene, Accession # | n/a |
Catalog # | HM1111 |
Price | |
Order / More Info | TIM-4, Mouse Antibody from HYCULT BIOTECH |
Product Specific References | n/a |
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