| 产品详情 |
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| Antigenic Specificity | TIM-4, Mouse |
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| Clone | Kat5-18 |
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| Host Species | Armenian hamster |
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| Reactive Species | mouse |
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| Isotype | IgG |
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| Format | unconjugated |
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| Size | 0.5 mg |
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| Concentration | 100 µg/ml |
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| Applications | FC, functional studies, immunoassay, IF |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The monoclonal antibody Kat5-18 recognizes T-cell immunoglobulin and mucin domain containing molecule (TIMD-4, also called TIM-4). TIMD-4 is a type I transmembrane protein belonging to the immunoglobulin superfamily, containing one Ig-like V-type (immunoglobulin-like) domain. TIMD-4 is expressed in Mac1+ cells in spleen, lymph nodes and fetal liver. TIMD-4 binds apoptotic cells by recognizing phosphatidylserine via its immunoglobulin domain. TIMD-4 in fibroblasts enhanced their ability to engulf apoptotic cells. TIMD-4 is involved in regulating T-cell proliferation and lymphotoxin signaling. TIMD-4 and TIMD-1 are phosphatidylserine receptors for the engulfment of apoptotic cells, and are also involved in intracellular signaling in which exosomes are involved. The monoclonal antibody Kat5-18 blocks the engulfment of apoptotic cells by thymic macrophages. |
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| Immunogen | Mouse peritoneal cells |
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| Other Names | TIMD4, TIM-4, T-cell immunoglobulin and mucin domain containing molecule |
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| Gene, Accession # | n/a |
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| Catalog # | HM1111-FS |
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| Price | |
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| Order / More Info | TIM-4, Mouse Antibody from HYCULT BIOTECH |
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| Product Specific References | n/a |
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