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| Antigenic Specificity | Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C) (aa 50-100) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, rat, mouse |
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| Isotype | n/a |
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| Format | unconjugated |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (IHC),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds.Subcellular location: Membrane, Multi-pass membrane protein.Tissue specificity: Expressed in brain, heart, jejunum, ovary, pancreatic beta-cells and vascular smooth muscle. Overall expression is reduced in atherosclerotic vascular smooth muscle. Also known as: CACH2, CACN2, CACNL1A1, CCHL1A1, Voltage-gated calcium channel subunit alpha Cav1.2, Calcium channel, L type, alpha-1 polypeptide, cardiac muscle, Voltage dependent L-type calcium channel subunit alpha-1C. |
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| Immunogen | A synthetic peptide from aa region 50-100 of human CACNA1C conjugated to an immunogenic carrier protein was used as the antigen. The antigen shares 96% identity with mouse, rat and rabbit sequence. |
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| Other Names | isl|C-LTCC|ICA|cav1.2|ca(v)1.2|CACH2|CACN2|CACNL1A1|CCHL1A1|CaV1.2|LQT8|TS|Cav1.2|Cchl1a1|MBC|MELC-CC|RATIVS302|CAV1.2|CHCACHA1C|CACH2C|Cacna1c |
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| Gene, Accession # | Gene ID: 775,12288,24239 |
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| Catalog # | ABIN350137 |
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| Order / More Info | Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C) (aa 50-100) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 17224476, 16541075, 8392192, 7737988, 9607315 |
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