| 产品详情 |
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| Product Name | SHIP2 Inhibitor, AS1938909 |
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| Description | Purity ~99% (HPLC). A cell-permeable thiophenecarboxamide compound that is shown to increase glucose metabolism and activate intracellular insulin signaling. Acts as a potent, competitive and reversible inhibitor of SHIP2 activity (Ki=0.44uM for hSHIP2) with moderate to excellent selectivity over SHIP1 and other related phosphatases (IC50=0.18, 0.57, 21, >50, >50 and >50uM for mSHIP2, hSHIP2, hSHIP1, hPTEN, h-synaptojanin and h-myotubularin, respectively). Elevates insulin-induced pAkt-Ser473 levels and enhances glucose transporter GLUT1 mRNA expression in L6 myotubes. SHIP1 Inhibitor, 3AC is also available. Formula: C20H18ClNO2S Solubility: DMSO Molecular Weight: 371.9 |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | SHIP2 Inhibitor, AS1938909 (3-(2,4-Dichlorobenzyl)oxy]-N-(2,6-difluorobenzyl)thiophene-2-carboxamide, SH2 Domain-containing Inositol 5'-phosphatase 2 (SHIP2) Inhibitor) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217790 |
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| Order / More Info | SHIP2 Inhibitor, AS1938909 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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