| 产品详情 |
| Edit |   |
|---|
| Product Name | PluriSln 1 |
|---|
| Description | Purity >95%. PluriSln 1 is an N-acyl phenylhydrazine derivative that inhibits stearoyl-CoA desaturase, a key enzyme for lipid metabolism that is expressed in human pluripotent stem cells (hPSCs). PluriSln 1 can selectively induce ER stress, attenuate protein synthesis, and induce apoptosis in hPSCs (EC50 = 2 µM) while sparing progenitor and differentiated cells. Because PluriSln 1 can selectively eliminate undifferentiated hPSCs, it was developed as a strategy to prevent tumorigenic risk from residual undifferentiated cells used during stem cell therapy. In immunocompromised mice, PluriSln 1 has been shown to effectively prevent teratoma formation from undifferentiated hPSCs. |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 2-phenylhydrazide-4-pyridinecarboxylic acid, N'-phenyl-hydrazine-Isonicotinic acid, NSC 14613 |
|---|
| Gene, Accession, CAS # | CAS: 91396-88-2 |
|---|
| Catalog # | LS-H9461 |
|---|
| Price | |
|---|
| Order / More Info | PluriSln 1 from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|