| 产品详情 |
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| Product Name | CDDO-Me |
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| Description | Purity ~98% (HPLC). A cell-permeable, bioavailable synthetic oleanane triterpenoid compound with anti-inflammatory, anti-tumor and cytoprotective properties. Shown to significantly reduce the expression of several inflammatory mediators, including IL-6, IL-10, IL-12, TNFalpha, Mip1alpha and others. Reverses high fat diet-induced type 2 diabetes in C57BL/6 mice (3mg/kg) and improves glucose homeostasis and insulin sensitivity. Down-regulates lipogenic gene expression in hepatocytes. Exhibits anti-proliferative activity in osteosarcoma cells (IC50 = 800, 150, 330, and 170nM in HOB-c, KHOS, KHOSR2, and U2OS cells, respectively). Enhances the effectiveness of chemotherapeutic agents by inducing intrinsic mitochondrial-dependent apoptotic pathway. Reported to interact with multi cellular targets, namely, Nrf2-Keap1, IKK, JAK-STAT, PPARg, ErbB2, PTEN, mTOR and Arp3 and covalently modify active site Cys residue via Michael addition. Solubility: DMSO |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CDDO-Me (NSC 713200, Bardoxolone Methyl, BARD, Methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217264 |
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| Order / More Info | CDDO-Me from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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