| 产品详情 |
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| Product Name | CDDO methyl ester |
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| Description | Purity >98%. The synthetic oleanane triterpenoid CDDO is a Nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells. The C-28 methyl ester of CDDO (CDDO methyl ester) blocks the cellular synthesis of inducible nitric oxide synthase (iNOS) and inducible COX-2 in INF-Gamma-activated mouse macrophages with an IC50 value of 0.11 nM. It induces apoptosis, induces differentiation, and inhibits the inflammatory response in various tumor cells through inhibition of I?BAlpha kinase/NF-?B signaling. CDDO methyl ester has potent antidiabetic activity, reducing proinflammatory cytokine expression in high fat diet-fed type 2 diabetic mice and in Leprdb/db mice and triggering AMP-activated protein kinase and LKB1 activation in muscle and liver. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-cyano-3,12-dioxo-oleana-1,9(11)-dien-28-oic acid, methyl ester, RTA 402, Bardoxolone methyl, NSC 713200, TP-155 |
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| Gene, Accession, CAS # | CAS: 218600-53-4 |
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| Catalog # | LS-H7040 |
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| Price | |
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| Order / More Info | CDDO methyl ester from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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