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| Product Name | Mitochondrial Fusion Promoter, M1 |
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| Description | Purity ~98% (HPLC). A cell-permeable phenylhydrazone that restores mitochondrial tubular network formation in MEF lacking either of the two outer mitochondrial membrane (OMM) mitofusins (EC50=5.3 and 4.42 mM, respectively, in Mfn1 or Mfn2 knockout MEF cells) or in MPP+-treated SH-SY5Y cells (5uM 24h), but not in MEF lacking both Mfn1/2 or the inner mitochondrial membrane (IMM) fusion mediator Opa1 (optic atrophy1). M1 (5uM 24h) is reported to boost the downregulated ATP5A & ATP5B protein level in Mfn1 or Mfn2 knockout MEF to the wild-type MEF level and ATPase inhibitor oligomycin at 5uM is shown to completely offset the mitochondrial fusion effect by 5uM M1 in Mfn1 knockout MEF. Comparing to mdivi-1, M1 exerts its effect via promoting fusion rather than inhibiting fission or division. Formula: C14H10Cl4N2O Molecular Weight: 364.1 Solubility: DMSO (25mg/ml) |
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| Size | 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Mitochondrial Fusion Promoter, M1 ((E)-4-Chloro-2-(1-(2-(2,4,6-trichlorophenyl)hydrazono)ethyl)phenol) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217554 |
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| Order / More Info | Mitochondrial Fusion Promoter, M1 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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