| 产品详情 |
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| Product Name | PI3-Kinase Alpha Inhibitor 2 |
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| Description | Purity >98%. Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3 . PI3KAlpha, Beta, and Delta are class 1A enzymes composed of p110 and p85 subunits, whereas PI3KGamma is a class 1B PI3K composed of a p110 catalytic subunit and a p101 or p84 regulatory subunit. PI3KAlpha inhibitor 2 is a selective inhibitor of PI3KAlpha with IC50 values of 2, 16, 660, and 220 nM for the Alpha, Beta, Gamma, and 2CBeta isoforms, respectively. It inhibits PKA, KDR, PKCAlpha, and cyclin E/Cdk2 significantly less effectively (IC50 = 91, 3.4, 466, and 28 µM, respectively). PI3KAlpha inhibitor 2 inhibits A375 melanoma cell proliferation with an IC50 value of 580 nM. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-[4-(4-morpholinyl)thieno[3,2-d]pyrimidin-2-yl-phenol, Phosphatidylinositol 3-Kinase Alpha Inhibitor 2, PI3KAlpha Inhibitor 2 |
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| Gene, Accession, CAS # | CAS: 371943-05-4 |
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| Catalog # | LS-H9403 |
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| Order / More Info | PI3-Kinase Alpha Inhibitor 2 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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