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| Product Name | Di-Ubiquitin (K48-linked) |
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| Description | Purity ~95% (SDS-PAGE). Poly-ubiquitylation of target proteins through linkage at K48, is now the most thoroughly studied of the various chain linkages, and was once considered the hallmark of this post-translational modification. It is now clear that many, if not all, poly-Ub chain topologies likely play distinct and important roles in regulating cellular processes. Nevertheless, K48 linkage remains a critical pathway for the cells to maintain homeostasis through proteolytic degradation, and as such remains very intriguing for the study of DUBs that play a role in the degradation, as well as the proteasome itself. These di-ubiquitin chains are generated from the enzymatic linkage (E2-25K) of wild-type ubiquitin through lysine 48. The most distal ubiquitin contains an arginine substitution for a lysine at position 48, limiting the chain length. Molecular Weight: ~17.14kD (Band migrates faster on gels) |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SUMO2, Gene ID: 6613, SwissProt: P61956 |
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| Catalog # | 219685 |
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| Order / More Info | Di-Ubiquitin (K48-linked) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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