| 产品详情 |
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| Product Name | FMS/KIT Dual Kinase Inhibitor, PLX647 |
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| Description | Purity ~98% (HPLC). A cell-permeable and bio-available azaindolylmethylpyridamine derivative that acts as a potent inhibitor against FMS and KIT (IC50 = 28 and 16nM, respectively) by targeting the kinases in their inactive DGF-out conformation, while being less effective against Flt3, KDR/VEGFR2, CDC2L6/CDK11/CDK19, NTRK3/TrkC, DDR2, CDK8/cyclin C (IC50 = 91, 130, 350, 620, 700, and 710nM, respectively) and exhibiting much reduced or little potency toward other kinases in a 400-kinase panel study (IC50 >1uM). Shown to effectively inhibit cellular FLT3-ITD, FMS, KIT phosphorylations (IC50 from 20 to 250nM), as well as FLT3-ITD-, FMS-, KIT-dependent proliferations (IC50 from 92 to 380nM). Exhibits in vivo efficacy in several murine inflammation models (20 to 80mg/kg b.i.d.; p.o.) and in preventing rat MRMT-1 breast carcinoma bone metastases-caused osteolysis (30mg/kg b.i.d.; p.o.). Alternate Names: PLX-647, c-Kit Inhibitor IV, CDC2L6/CDK11/CDK19 Inhibitor, CDK8 Inhibitor, cFMS Inhibitor |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | FMS/KIT Dual Kinase Inhibitor, PLX647 (CDC2L6/CDK11/CDK19 Inhibitor, CDK8 Inhibitor, cFMS Inhibitor V, CSF-1 Receptor Inhibitor V, CSF1R Inhibitor V, DDR2 Inhibitor II, Flt-3 Inhibitor VIII, IL-34 Receptor Inhibitor V, NTRK3/TrkC Inhibitor, VEGFR Tyrosine Kinase Inhibitor XXXVI, VEGFR2 Tyrosine Kinase Inhibitor XXXIV, PLX-647, c-Kit Inhibitor IV) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217366 |
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| Order / More Info | FMS/KIT Dual Kinase Inhibitor, PLX647 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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