| 产品详情 |
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| Product Name | Cercosporamide |
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| Description | Purity >95%. Cercosporamide is a natural antifungal phytotoxin isolated from the Cercosporidium fungus, which infects the leaves of cassava plants. Its antifungal effect results from its selective and potent inhibition of fungal PKC-like 1 kinases (Pkc1), which are central to cell wall integrity (IC50 = 25 nM for Candida Pkc1). Cercosporamide less effectively inhibits human PKC isoforms PKCAlpha, Beta, and Gamma (IC50 s = 1.02, 0.35, and 5.8 µM, respectively), an action linked to lowering of plasma glucose in hyperglycemic mice. However, it potently inhibits MAPK-interacting kinases Mnk1 and Mnk2 (IC50 = 115 and 11 nM, respectively), reducing protein translation in cancer cells. Cercosporamide is orally bioavailable. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (9aS)-8-acetyl-9,9a-dihydro-1,3,7-trihydroxy-9a-methyl-9-oxo-4-dibenzofurancarboxamide |
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| Gene, Accession, CAS # | CAS: 131436-22-1 |
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| Catalog # | LS-H7077 |
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| Price | |
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| Order / More Info | Cercosporamide from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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