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| Product Name | 4-hydroxy Nonenal Mercapturic Acid-d3 |
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| Description | Purity >99%. 4-hydroxy Nonenal mercapturic acid-d3 contains three deuterium atoms at the terminal methyl position. It is intended for use as an internal standard for the quantification of 4-HNE mercapturic acid by GC- or LC-mass spectrometry. Peroxidation of common ?-6 polyunsaturated fatty acids (PUFAs) such as linoleic acid, DGLA, and arachidonic acid can give rise to 4-HNE. 4-HNE is cleared rapidly from the plasma and undergoes enterohepatic circulation as a glutathione conjugate in the rat. About two thirds of an administered dose of 4-HNE is excreted within 48 hours in the urine, primarily in the form of mercapturic acid conjugates. The C-1 aldehyde of 4-HNE is reduced to an alcohol in about half of these metabolites. The remainder are C-1 aldehydes or have been oxidized to C-1 carboxylic acids. These aldehydes and carboxylic acids can also form Gamma-lactols and Gamma-lactones, respectively, producing at least four or five end urinary metabolites of 4-HNE in vivo . |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-acetyl-S-(tetrahydro-5-hydroxy-2-pentyl-3-furanyl)-L-cysteine-11,11,11-d3 |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | LS-H6125 |
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| Order / More Info | 4-hydroxy Nonenal Mercapturic Acid-d3 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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