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| Product Name | Okadaic Acid |
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| Description | Purity >95%. Okadaic acid is a marine sponge toxin which potently inhibits certain serine/threonine protein phosphatases. This cell permeable inhibitor targets the multiple isoforms of PP1 (IC50 = 10-50 nM), both isoforms of PP2A (IC50 = 0.5 nM) and PP3 (IC50 = 4 nM). It is a very weak inhibitor of PP2B (IC50 > 2 µM) and does not inhibit PP2C or other phosphatases. Presumably through these actions, okadaic acid is a potent carcinogen and induces tau phosphorylation. In sponge, okadaic acid plays a role in defense, inducing apoptosis in symbiotic or parasitic annelids. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (6R)-aR,5R-dihydroxy-a,10-dimethyl-8S-[(2E)-1R-methyl-3-[(2R,4'aR,8'aS)-octahydro-8'R-hydroxy-6'S-[1S-hydroxy-3S-[(6S)-3R-methyl-1,7-dioxaspiro[5.5]undec-2S-yl]butyl]-7'-methylenespiro[furan-2(3H),2'(3'H)-pyrano[3,2-b]pyran]-5R-yl]-2S-propen-1-yl]-1,7-dio, OA, 35-demethyl DTX1, Acanthifolicin, NSC 677083 |
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| Gene, Accession, CAS # | CAS: 78111-17-8 |
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| Catalog # | LS-H9152 |
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| Order / More Info | Okadaic Acid from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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