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| Product Name | Iron Chelator IV, 21H7 (6-Bromo-N'-(2-hydroxybenzylidene)-2-methylquinoline-4-carbohydrazide) |
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| Description | Purity ~97% (HPLC). A cell-permeable salicylaldehyde-acylhydrazone iron chelator that is 20-times more efficient than DFO/desferrioxamine in depleting intracellular iron in colon cancer SW480 cells. Iron chelators exert their biological activities by affecting iron-regulated enzymes and singaling events, including HIF1a transcription activation due to inhibition of PHD- (prolyl hydroxylase) mediated HIF1a degradation, as well as altered mRNA translations due to enhanced IRP (Iron Regulatory Protein) IREs (Iron Response Elements) binding. Cellular iron depletion is also reported to inhibit the growths of colorectal adenocarcinoma cultures, DLD-1 (IC50=0.6 and 2.9uM, respectively, by 21H7 and DFO) and SW480 (IC50=1.0 and 3.8uM, respectively, by 21H7 and DFO), as a result of Wnt signaling pathway blockage (Effective conc.=5uM 21H7 or 100uM DFO). Formula: C18H14BrN3O2 Molecular Weight: 384.2 Solubility: DMSO (5mg/ml light yellow solution) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217467 |
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| Order / More Info | Iron Chelator IV, 21H7 (6-Bromo-N'-(2-hydroxybenzylidene)-2-methylquinoline-4-carbohydrazide) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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