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| Product Name | PTEN, Recombinant, Human |
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| Description | Purity ~90% (SDS-PAGE). PTEN, a tumor suppressor, has been implicated in a large number of human tumors and is conserved from humans to worms. Characterization of PTEN protein showed that it is a phosphatase that acts on proteins and on 3-phosphorylated phosphoinositides, and can therefore modulate signal-transduction pathways that involve lipid second messengers. Recent results indicate that at least part of its role is to regulate the activity of the serine/threonine kinase AKT/PKB, and thus influence cell survival signaling. Source: Recombinant protein corresponding to human PTEN, expressed in E. coli. Molecular Weight: ~80kD Biological Activity: A Phosphatase specific activity of ~400nmol/min/mg was determined using the substrate phosphatidylinositol (3,4,5) triphosphate at a final concentration of 125mM in 20mM Tris, pH 7.5, 150mM NaCl, 50mM MgCl2, 0.05% Tween-20, 0.2% 2-mercaptoethanol. Endotoxin: <0.1ng/ug |
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| Size | 5ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PTEN, Recombinant, Human (Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and Dual-specificity Protein Phosphatase PTEN, Phosphatase and Tensin Homolog, Mutated in Multiple Advanced Cancers 1, PTEN, MMAC1, TEP1, BZS, MHAM, PTEN1, 10q23del) |
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| Gene, Accession, CAS # | PTEN, Gene ID: 5728, SwissProt: P60484 |
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| Catalog # | 220209 |
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| Order / More Info | PTEN, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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