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| Product Name | PTEN Tumor Suppressor Protein, Recombinant, Human |
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| Description | Purity ~85% by SDS-PAGE Purified by immunoaffinity chromatography. PTEN, also known as phosphatase and tensin homolog, is a tumor suppressor that is mutated in a large number of cancers at high frequency. This protein acts as both a dual-specificity protein phosphatase and a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate. PTEN negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. Recombinant PTEN protein, expressed in E. coli and purified by using conventional chromatography techniques. Source: Recombinant human PTEN, aa1-403, His-tagged, expressed in E. coli AA Sequence: MGSSHHHHHH SSGLVPRGSH MTAIIKEIVS RNKRRYQEDG FDLDLTYIYP NIIAMGFPAE RLEGVYRNNI DDVVRFLDSK HKNHYKIYNL CAERHYDTAK FNCRVAQYPF EDHNPPQLEL IKPFCEDLDQ WLSEDDNHVA AIHCKAGKGR TGVMICAYLL HRGKFLKAQE ALDFYGEVRT RDKKGVTIPS QR |
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| Size | 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PTEN Tumor Suppressor Protein, Recombinant, Human (PTEN1, MMAC1, Phosphatase and Tensin, TEP1, BZS, MHAM) |
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| Gene, Accession, CAS # | Accession: NP_000305 |
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| Catalog # | P9182-03D |
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| Order / More Info | PTEN Tumor Suppressor Protein, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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