| 产品详情 |
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| Product Name | SC66, Akt Inhibitor XVIII ((2E,6E)-2,6-bis(4-Pyridylmethylene)cyclohexanone) |
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| Description | Purity ~95% (HPLC). A cell-permeable pyridine compound that selectively targets Akt, but not PLCd, PH domain, preventing Akt membrane localization/activation and rendering Akt in a conformation susceptible to ubiquitination and subsequent proteasomal degradation. Akti-1/2 competes for Akt PH domain binding and blocks SC66-induced Akt ubiquitination and proteasomal degradation. Effectively inhibits HEK293T growth both in vitro (>99 inhibition at 0.4uM) and in mice in vivo (84% of control tumor size with twice weekly i.p. dose of 30mg/kg), Synergizes with LY294002 in cell death induction in HeLa and HS-Sultan cultures in vitro. Formula: C18H16N2O Molecular Weight: 276.3 Solubility: DMSO (25mg/ml) |
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| Size | 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217784 |
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| Order / More Info | SC66, Akt Inhibitor XVIII ((2E,6E)-2,6-bis(4-Pyridylmethylene)cyclohexanone) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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