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| Product Name | Recombinant Human Receptor-interacting serine/threonine-protein kinase 2 |
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| Description | 1-540aa; Full Length. MW: 65.3kD. Purity >90% as determined by SDS-PAGE. Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 auto |
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| Size | 0.01 mg (E-Coli), 0.05 mg (E-Coli), 0.1 mg (E-Coli), 0.2 mg (E-Coli), 0.5 mg (E-Coli) |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD-containing IL-1 beta ICE-kinase; RIP-like-interacting CLARP kinase; Receptor-interacting protein 2; RIP-2; Tyrosine-protein kinase RIPK2 (EC:2.7.10.2)] |
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| Gene, Accession, CAS # | RIPK2, Gene ID: 8767, Accession: NP_003812.1 |
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| Catalog # | MBS1174923 |
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| Order / More Info | Recombinant Human Receptor-interacting serine/threonine-protein kinase 2 from MYBIOSOURCE INC. |
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| Product Specific References | RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis.Inohara N., del Peso L., Koseki T., Chen S., Nunez G.J. Biol. Chem. 273:12296-12300(1998) RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase.McCarthy J.V., Ni J., Dixit V.M.J. Biol. Chem. 273:16968-16975(1998) Identification of CARDIAK, a RIP-like kinase that associates with caspase-1.Thome M., Hofmann K., Burns K., Martinon F., Bodmer J.-L., Mattmann |
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