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| Product Name | Recombinant Human Receptor tyrosine-protein kinase erbB-2 |
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| Description | 153-598aa; Partial. MW: 53.2kD. Purity >90% as determined by SDS-PAGE. Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MO1-RHOA-DIAPH1 signaling pathway elic |
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| Size | 0.01 mg, 0.05 mg, 0.1 mg, 0.2 mg, 0.5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD340] |
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| Gene, Accession, CAS # | ERBB2, Gene ID: 2064, Accession: NP_001005862.1 |
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| Catalog # | MBS1265578 |
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| Order / More Info | Recombinant Human Receptor tyrosine-protein kinase erbB-2 from MYBIOSOURCE INC. |
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| Product Specific References | Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor.Yamamoto T., Ikawa S., Akiyama T., Semba K., Nomura N., Miyajima N., Saito T., Toyoshima K.Nature 319:230-234(1986) Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.Coussens L., Yang-Feng T.L., Liao Y.C., Chen E., Gray A., McGrath J., Seeburg P.H., Libermann T.A., Schlessinger J., Francke U., Levinson A., Ullrich A.Science 230:1132-1139(1985) |
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