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| Product Name | SB 431542 |
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| Description | SB 431542 is a potent and selective inhibitor of the TGF-β1 receptor ALK5 (IC50 = 94 nM)1. It inhibits ALK4 only at higher concentrations (IC50 = 140nM). It is a less potent antagonist of ALK4 (IC50 = 140 nM)2 and ALK7.3 It does not affect the BMP receptors ALK2, ALK3, ALK6, or a panel of other kinases tested.3 SB 431542 specifically blocks Smad signaling, reducing gene expression relevant to fibrosis and cancer.3 Through its effects on ALK/Smad signaling, SB 431542 suppresses renewal in embryonic and induced pluripotent stem cells and promotes their differentiation.4,5 Molecular Weight: ~384.39 Solubility: DMSO: 10mg/ml, soluble H2O: Insoluble |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 166491 |
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| Price | |
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| Order / More Info | SB 431542 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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| 产品资料 |
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