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| Product Name | SB 202190 |
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| Description | Purity >97%. SB 202190 is a selective, potent, cell-permeable inhibitor of p38 MAP kinases, inhibiting p38 alpha (SAPK2A, MAPK14) and p38 beta (SAPK2B, MAPK11) with IC50 values of 50 and 100 nM, respectively. When tested at 10 µM, SB 202190 has negligible effects on a range of other kinases, including other MAP kinases (ERKs, JNKs). Pyridinyl imidazole inhibitors, including this compound, directly bind p38 MAP kinases in the ATP binding pocket. Recently, SB 202190 has been used to elucidate the roles of p38 MAP kinases in inflammatory cytokine expression, nicotine-induced receptor expression, and HIV-mediated depressive disorder. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-phenol |
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| Gene, Accession, CAS # | CAS: 152121-30-7 |
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| Catalog # | LS-H49 |
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| Order / More Info | SB 202190 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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