| 产品详情 |
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| Product Name | Indomethacin, 2'-Trifluoromethyl |
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| Description | Purity ~98% (HPLC). A cell-permeable, bioavailable 2'-trifluoromethyl analog of Indomethacin that acts as a highly potent, time-dependent inhibitor of cyclooxygenase -2 (COX-2; IC50 = 267 and 388nM for mouse and human COX-2, respectively) and its several mutant forms. Does not affect COX-1 activity even at high concentrations (IC50 >100uM). Interacts with human COX-2 with much greater affinity than indomethacin (KI = 1.5 vs 13uM) and blocks COX-2 dependent arachidonic acid oxygenation (IC50 = 150nM in 1483 human head and neck squamous cell carcinoma cells). Further, minimizes swelling in carrageenan-induced rat paw edema model (EC50 = 1.7mg/kg, p.o.) with no gastrointestinal bleeding at higher doses (10mg/kg). Primary Target: COX-2 Primary Target IC50: 267 and 388nM for mouse and human COX-2, respectively. Solubility: DMSO |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Indomethacin, 2'-Trifluoromethyl (Indomethacin, 2'-Trifluoromethyl, Indomethacin, 2-CF3, CF3-Indomethacin, CF3-INDO) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217456 |
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| Order / More Info | Indomethacin, 2'-Trifluoromethyl from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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