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| Product Name | XRCC6, Recombinant, Human, aa6-222, His-Tag (X-ray Repair Cross-complementing Protein 6) |
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| Description | Purity ~90% (SDS-PAGE). Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dR |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5'-deoxyribose-5-phosphate lyase Ku70, 5'-dRP lyase Ku70 70kD subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 1, ATP-dependent DNA helicase II, 70kD subunit CTC box-binding factor, 75kDa subunit, CTC75,CTCBF DNA repair protein XR, CC6 Lupus Ku autoantigen protein p70, Ku70 Thyroid-lupus autoantigen, TLAAX-ray repair complementing defective repair in Chinese hamster cells 6 |
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| Gene, Accession, CAS # | SwissProt: P12956 |
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| Catalog # | 375885 |
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| Order / More Info | XRCC6, Recombinant, Human, aa6-222, His-Tag (X-ray Repair Cross-complementing Protein 6) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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