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| Product Name | Efna5, Recombinant, Rat, aa21-203, His-Tag (Ephrin-A5) |
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| Description | Purity ~85% (SDS-PAGE). Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the Extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fascicu |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | AL-1 EPH-related receptor tyrosine kinase ligand 7, LERK-7 |
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| Gene, Accession, CAS # | SwissProt: P97605 |
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| Catalog # | 373140 |
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| Order / More Info | Efna5, Recombinant, Rat, aa21-203, His-Tag (Ephrin-A5) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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