| 产品详情 |
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| Product Name | U0126 |
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| Description | MW: 380.5. Purity >98% (TLC); NMR (Conforms). U-0126 is a novel, potent and selective MEK inhibitor (MEK1; IC50=72 nM, MEK2; IC50=58 nM) (1,2). Blocks the production of inflammatory cytokines and prostaglandin E2 in LPS-stimulated monocytes (3) and displays anti-inflammatory activity (4). An extremely useful tool for exploring pathways dependent on MEK activity. |
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| Size | 10 mg, 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [1,4-Diamino-2,3-dicyano-1,4-bis[2-a-minophenylthio]butadiene] |
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| Gene, Accession, CAS # | CAS: 109522-58-2 |
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| Catalog # | MBS515067 |
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| Order / More Info | U0126 from MYBIOSOURCE INC. |
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| Product Specific References | JV Duncia et al. Bioorg. Med. Chem. Lett. 1998 8:2839 MF Favata et al. J. Biol. Chem. 1998 273:18623 PA Scherle et al. J. Immunol. 1998 161:5681 BD Jaffee et al. Biochem. Biophys. Res. Commun. 2000 268:647 |
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