| 产品详情 |
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| Product Name | U-0126 |
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| Description | MW: 380.5. Purity >98% (TLC: 10% CH3OH in CH2Cl2, Rf=0.25); NMR (Conforms). MEK1/2 inhibitorPotent and selective p38 MAP kinase inhibitor acting at the ATP site1. Selectively inhibits the p38 and isoforms (IC50= 50 and 100 nM for SAPK2a/p38 and SAPK2b/p38 2 respectively)2. Effectively blocks LPS-induced gene expression in monocytes3. Induces apoptosis4. Cell permeable.Scientific Background: U-0126 is a novel, potent and selective MEK inhibitor (MEK1; IC50=72 nM, MEK2; IC50=58 |
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| Size | 10 mg, 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [SB 202190; 4-[4-(4-Fluorophenyl)-5-(4-pyridiny~l)-1H-imidazol-2-yl] phenol; 1,4-Diamino-2,3-dicyano-1,4-bis [2-aminophenylthio] butadiene] |
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| Gene, Accession, CAS # | CAS: 109522-58-2 |
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| Catalog # | MBS515018 |
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| Order / More Info | U-0126 from MYBIOSOURCE INC. |
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| Product Specific References | PR Young et al. J. Biol. Chem. 1997 272:12116 2. SP Davies et al. Biochem. J. 2000 351:95 3. CL Manthey et al. J. Leukoc. Biol. 1998 64:409 4. S Nemoto et al. J. Biol. Chem. 1998 273:16415 |
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