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| Product Name | U-104 |
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| Description | MW: 309.32. Purity ≥98% by HPLC. U-104 is a ureido-sulfonamide inhibitor of transmembrane carbonic anhydrase IX (CAIX) (Ki = 45.1 nM) and XII (CAXII) (Ki = 4.5 nM). It displays weaker affinity for the cytosolic isoforms; CAI and CAII (Kis = 5.08 and 9.64 uM; respectively). U-104 associates with CAIX/CAXII only under hypoxic conditions in vivo; reducing extracellular acidity and resulting in significant inhibition of tumor growth and metastasis in experimental models. |
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| Size | 5 mg, 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [1- (4-fluorophenyl)-3- (4-sulfamoylphenyl) urea; NSC-213841] |
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| Gene, Accession, CAS # | CAS: 178606-66-1 |
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| Catalog # | MBS845810 |
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| Order / More Info | U-104 from MYBIOSOURCE INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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